Lady Gaga co-founder Michael Polansky's startup Outer Bio emerged from stealth with Yuna, a platform that feeds living skin experiments into an AI loop that now proposes a new skincare compound every six weeks.
Researchers used AlphaFold and directed evolution to build CMLase, an enzyme that stripped aging damage from 75-year-old skin tissue down to levels seen in 31-year-old samples. Proof of concept, not a cream yet, but a real applied-AI win in protein engineering.
Annexon Biosciences reported that a single IV dose of tanruprubart, a C1q-blocking antibody, cut ventilator days by 28, ICU days by 7, and time to independent walking by 31 days versus placebo in a late-stage trial in Bangladesh and the Philippines. EMA review is underway for possible 2027 approval.